Just hours after being unveiled as a projected No. 1 seed for the NCAA Tournament in the top 16 in-season reveal, Iowa State basketball stumbled and suffered a 79-69 road loss at BYU on Saturday, Feb. 21. BYU had a 13-0 run towards the end of the first half, which helped the Cougars take a 39-30 halftime lead.

The Iowa State Cyclones are going to face some challenges in their game against the BYU Cougars.

Building off that last-minute second-quarter run, BYU scored seven quick points to start the third. Lara Rohkohl hit two shots inside, and Kambree Barber hit a 3 after a Utah turnover, making the score 43-29 before fans had settled back into their seats after intermission.

We're betting on the Cyclones to beat a banged-up Cougars squad in our Iowa State vs. BYU predictions and betting picks for February 21.

The Iowa State Cyclones are heading to Provo, Utah, to face their third ranked opponent in a row in the BYU Cougars.

Despite winning two straight games, BYU has fallen a spot in the national rankings.

Michigan State and Ohio State will meet for the first time on the hardwood this season Sunday on CBS in a pivotal Big Ten showdown with NCAA Tournament seeding and conference championship implications on the line.

Will the Iowa State Cyclones be able to get a signature road win?