Final Four picks, predictions, odds explain why Houston Cougars will beat Duke Blue Devils in NCAA Tournament March Madness game Saturday, April 5.

The SportsLine Projection Model has revealed its Houston Cougars vs. Duke Blue Devils picks for the Final Four of the 2025 NCAA Tournament on Saturday

HOUSTON — University of Houston fans are welcome to one of more than a dozen watch parties hosted by alumni associations across the counter. The UH men’s basketball team will face off against Duke on Saturday in the Final Four of the NCAA Tournament at the Alamodome in San Antonio.

The Auburn Tigers and Florida Gators meet in an all-SEC clash to kick off the Final Four on Saturday. Then, the Duke Blue Devils square off with the Houston Cougars in the nightcap in San Antonio. Each battle between No. 1 seeds could produce games that are talked about for decades.

The Final Four in the men's NCAA Tournament is set, with all four No. 1 seeds -- Duke, Florida, Houston and Auburn -- winning their respective regions and advancing to San Antonio this weekend.

Madness odds for Houston Cougars vs Duke Blue Devils Final Four NCAA Tournament game, including point spread, moneyline, over/under for betting.

Here’s a look at the odds to win the Final Four ahead of Saturday’s March Madness semifinals. Duke is the Final Four favorite at +100 odds at bet365 as of April 2, 2025. That price is warranted considering the talent of this Duke Blue Devils squad, but it also reflects a season’s worth of NCAA Tournament futures piling up on the Dukies.

Expect a slow-paced slugfest between Duke and Houston — and a relatively comfortable Florida win over Auburn.