The Miami Hurricanes lost their first game of the season on Friday, falling 24-21 to the Louisville Cardinals at Hard Rock Stadium.

MIAMI - Howard Schenellenberger's boots are coming back to the Derby City. Marching into South Florida for a primetime matchup with No. 2 Miami, the Louisville football program earned a massive statement, leaving Hard Rock Stadium with 24-21 victory.

The Louisville Cardinals made history they haven't seen since Lamar Jackson was their quarterback after stunning No. 2 Miami on Friday night.

Carson Beck threw four interceptions, including one with less than a minute left to play with Miami in range for a game-tying field goal.

Louisville won 24-21 after intercepting Miami quarterback Carson Beck four times, and it has now made program history per SportsCenter. The Cardinals got their second-ever win against an AP-Top 2 team. The AP Poll has existed since 1936, per AP. Meanwhile, Louisville football has been active since 1912, per the school’s website.

Louisville has pulled off a stunning victory against the second-ranked Miami Hurricanes, winning 24-21 on Friday night.

Miller Moss threw two touchdown passes to Chris Bell and ran for a score, and Louisville intercepted four of Carson Beck's passes.

Miami’s 10 game home winning streak ends to the last team to beat them in HRS 2 years ago: Louisville. AND I HATE IT!!!