"The 49ers today put Brandon Aiyuk on the reserve/left squad list, which officially ends his 2025 season. The reserve/left squad list is usually applied to players who plan to retire or who have quit their team," The Athletic's Matt Barrows wrote.

The San Francisco 49ers have elevated two players from the practice squad to bolster their defense in Sunday's Week 15 game vs. the Tennessee Titans.

The San Francisco 49ers are bringing up two players from the practice squad for their Week 15 battle with the Tennessee Titans.

Twice this season—once ahead of a Week 10 matchup against the Los Angeles Rams and again before Sunday's game against the Tennessee Titans—the San Francisco 49ers elevated defensive tackle Sebastian Valdez from the practice squad.

San Francisco 49ers head coach Kyle Shanahan has made a shocking admission about the fallout with Brandon Aiyuk.

The San Francisco 49ers have had a strong season while overcoming impactful injuries, but Kyle Shanahan says it isn't the team he's most proud of.

The 49ers welcomed youth from the 49ers Social Justice Grant recipient organizations for an Inspire Change mentorship cooking class focused on nutrition, hands-on learning, and building meaningful connections.

White, who died Sunday at the age of 89, played at Acalanes High and Cal, then coached the Bears, Stanford, Raiders and 49ers among others during his career.

Brandon Aiyuk’s time with the 49ers might be over. The wide receiver, who hasn’t played since he underwent right knee surgery in the middle of last season, was placed on the team’s reserve/left team list on Saturday.