The Atlanta Falcons are 3-2 after five weeks, but despite having the NFL's No. 1 ranked defense, those around the league have been hesitant to buy in just yet. That narrative could change if the Falcons are able to defeat the San Francisco 49ers on the road in Week 7.

The San Francisco 49ers will take on the Atlanta Falcons on Sunday at Levi's Stadium. Here's who is set to practice on Wednesday.

With Purdy out, Jones threw for 279 yards and three scores in the 49ers' Week 2 win over the Saints before throwing for 284 yards with a touchdown and a pick in San Francisco's Week 3 victory over the Cardinals .

San Francisco sits at 4-2 but mounting injuries have hurt the team's chances in 2025. Here are five trade targets who could help.

Christian McCaffrey has been a one-man playbook for the 49ers, and our expert SNF picks, odds & expert predictions expect McCaffrey to carry the load when they host the Atlanta Falcons on October 19.

Mac Jones will likely be the 49ers ' starting quarterback for Sunday's big road matchup against the Buccaneers, according to CBS Sports senior reporter Matt Zenitz, who is also reporting that Brock Purdy will reprise his role as San Francisco's QB1 when he is healthy enough to do so.

George Kittle said he plans to return in Week 7 vs. the Falcons after revealing his hamstring was fully torn in the 49ers’ opener.

The San Francisco 49ers could potentially be getting back star wide receiver Brandon Aiyuk at some point soon.