Three years ago, an NFL game between the Buffalo Bills and Cincinnati Bengals turned into a gut-retching moment when Bills safety Damar Hamlin suffered cardiac arrest and collapsed. Since then, Hamlin has made it his mission to increase awareness of CPR.

Joe Brady's predictable play-calling could doom the Buffalo Bills come playoff time, and it was shown why on Sunday against the Eagles.

Steve Tasker and Thurman Thomas will be the Bills Legends of the Game for the final regular season game at Highmark Stadium on Sunday

Nichols School alumna Hayley Scamurra will represent Western New York playing for the U.S. women’s hockey team at the 2026 Olympic Winter Games. This will be the second Olympic trip for Scamurra, who was raised in Getzville and played college hockey for Northeastern,

The final regular-season game held inside the current Highmark Stadium is set for Sunday against the New York Jets, and it’s sure to be a special day in Orchard

The Buffalo Sabres' surprising nine-game win streak has been achieved by a revitalized defense, timely offense and veteran player performances.

Before he is officially sworn in as the next Mayor of Buffalo, Sean Ryan sat down with 2 On Your Side to talk about his administration, taxes and more.

A new year means a new name for Buffalo’s Children’s Hospital. Beginning Jan. 1, Oishei Children’s Hospital is now known as the Golisano Children’s Hospital of Buffalo. The name change is in recognition of a $50 million donation from Paychex founder and former Buffalo Sabres owner Tom Golisano.

Emotions filled an Erie County courtroom Friday when two teenagers were sentenced for the shooting death of a 3-year-old boy, Ramone "Lucky" Carter, also known as "Red."