Translesion synthesis polymerases efficiently incorporate nucleotides opposite DNA lesions. Pol ι, for example, bypasses minor-groove and exocyclic purine adducts. Conventional X-ray crystallography ...

DNA polymerases orchestrate the faithful replication and repair of genomes through a coordinated sequence of substrate binding, chemical catalysis and product release. Central to this process are ...

Roughly 20 million people receive a cancer diagnosis each year, and an estimated 1 in 5 people will receive a cancer diagnosis in their lifetime. Cancer cells arise from damage to the cell's ...

A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, ...

Researchers at the Department of Energy's SLAC National Accelerator Laboratory have uncovered new insights into the fundamental mechanisms of RNA polymerase II (Pol II), the protein responsible for ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...

Researchers at UC San Diego have demonstrated that a key cellular enzyme can accurately read an eight-letter genetic alphabet, doubling the four letters used by all known life on Earth. Detailed ...