A research group at the Stowers Institute for Medical Research says it has put to rest the notion that a gene promoter is only a promoter. They report, in the current issue of eLife Sciences, that ...
The numbers of the principal regulatory elements present in insulin promoters are listed. Given the complexity and uncertainty of predicting the transcriptional outcome of mutations within regulatory ...
The nucleoside analog 5-aza-2′-deoxycytidine (5-aza-CdR, decitabine) is a potent inhibitor of DNA methylation in vitro. Cellular treatment with this agent induces the re-expression of ...
Clinical outcome of triple-negative primary breast cancer in older women: Comparison with their younger counterparts. Background: BRCA1 plays a central role repairing DNA double-strand breaks via ...
Yeast is a single cell eukaryotic organism, that incites in this Irish scientist an intense memory of the smell of brewing Guinness, wafting down the River Liffey on a drizzly Dublin day as I sit at ...
DNA sequences that regulate expression of the insulin gene are located within a region spanning ~400 bp that flank the transcription start site. This region, the insulin promoter, contains a number of ...
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