Newswise — CAMBRIDGE, Mass. (June 4, 2015) – Leveraging a novel system designed to examine the double-strand DNA breaks that occur as a consequence of gene amplification during DNA replication, ...
A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, ...
Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...
DNA replication and repair mechanisms constitute the foundation of genomic integrity, ensuring that genetic information is faithfully duplicated and maintained across cell generations. Replication ...
Reversed DNA replication forks protect against stress to maintain genomic stability and serve as central components to cancer resistance, disease suppression, aging and immunotherapy response ...
The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...
If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and the middle. Is everything packed? What time should we leave? Will there be ...
Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with ...
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