By combining CRISPR knock-in with small peptide tags, researchers can study proteins in their native cellular context, ...

Synthetic biology aims to modify cellular behaviors by implementing genetic circuits that respond to changes in cell state. Integrating genetic biosensors into endogenous gene coding sequences using ...

We perform intact proteoform profiling of 10,809 endogenous single cells from the rat hippocampus using single-cell proteoform imaging mass spectrometry (scPiMS). scPiMS directly extracts whole ...

For the 18 million people living with rheumatoid arthritis, disease management currently means a lifetime of injections-a ...

Recently, a research team led by Professor Zhengping Xu of Zhejiang University School of Medicine and its affiliated Sir Run Run Shaw Hospital published a paper in Science Bulletin titled ...

The researchers used lipid nanoparticles (LNPs) to deliver cyclic GMP-AMP (cGAMP) synthase (cGAS) mRNA to cancer cells. This results in production of the endogenous stimulator of interferon genes ...

Over the past decades, lineage tracing has been fundamental to unraveling how diverse cell types arise during development and how tumors evolve ...