Metabolites can inhibit the enzymes that generate them. To explore the general nature of metabolic self-inhibition, we surveyed enzymological data accrued from a century of experimentation and ...

Enzyme inhibitors play a pivotal role in pharmaceutical and nutraceutical industries. The primary understanding of the action of inhibitors helps pharmacologists during the design process for ...

Enzymes help with specific functions that are vital to the operation and overall health of the body. They help speed up chemical reactions in the human body. They are essential for respiration, ...

The goal of combining an ACE inhibitor with an ARB is to achieve a therapeutic outcome better than that achieved with either drug administered alone. The theoretic premise behind the combination of ...

The screening for enzyme inhibitors of microbial origin in the past decades has been a prosperous area to find new metabolites that are of potential importance as therapeutic or antibiotic agents.

Difluoromethylarginine (DFMA) and difluoromethylornithine (DFMO) are inhibitors of the polyamine biosynthetic enzymes arginine decarboxylase (ADC) and ornithine decarboxylase (ODC), respectively. DFMO ...