G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

A number of membrane proteins that are present on the cell membrane control external and internal material transportation, cell protection and signal transmission. The diversity of functions of ...

Purdue University scientists are deciphering an intricate cellular signaling system critical to immune response to better understand how it could be used to address multiple diseases, including cancer ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

A study published in Nature Structural & Molecular Biology is the first time researchers have shown evidence that a single ...

Researchers used AlphaFold3, the latest AI-based protein modeling system, to predict the structures of all 25 known human ...

In the search for answers about Alzheimer’s disease, researchers are taking a close look at the immune system of the brain. A ...

If future studies confirm the rescued receptors work normally, the study offers a new roadmap for rare disease drug development.

From September 1, 2021, to March 23, 2022, 33 patients were infused with anti-GPRC5D CAR T cells. At a median follow-up of 5.2 months (range, 3.2‐8.9), the overall response rate was 91% (95% CI, 76 to ...

In the march of metastasis, a molecular trail of crumbs guides some cancer cells from the primary tumor to establish new ...