Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor. That ...

Philadelphia, PA, 22 October 2009 - There are increasingly precise molecular insights into ways that stress exposure leads to fear and through which fear extinction resolves these fear states.

F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have prepared and tested cyclopenta-thieno-diazepine derivatives acting as GABA-A receptor subunit α2β2γ1 positive allosteric modulators (PAMs). As ...

Using a state-of-the-art method, researchers have succeeded for the first time at unraveling the effects of autoimmune antibodies, that are directed against the brain, in detail at the atomic level.

In humans and other animals, signals from a central circadian clock in the brain generate the seasonal and daily rhythms of life. They help the body to prepare for expected changes in the environment ...

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability. The cause, which has been well-studied, is the loss of fragile X mental retardation protein (FMRP)—a genetic ...