α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α ...

Organomagnesium compounds (Grignard reagents) are among the most useful organometallic reagents and have greatly accelerated the advancement of synthetic chemistry and related sciences. Nevertheless, ...

It is no longer necessary to use dialkylzinc reagents to obtain enantioselectivities >95% in the copper-catalyzed asymmetric conjugate addition of organometallic compounds to cyclic enones. We now ...

You asked how butyric acid is made we’ll explain the idea, not the instructions. Join us for a crash course on how chemists build carbon chains using Grignard reagents, some historical drama, and one ...

WeylChem has announced its intention to produce reagents on an industrial scale for major manufacturers of pharmaceuticals, agrochemicals and poly-functionalized products. A complete series of ...

Organic chemistry students and bench chemists alike rely on the Grignard reaction, a relatively simple way to make carbon-carbon bonds. But even though the reaction was first described 120 years ago, ...