The innate immune system constitutes the first line of defence against viral pathogens, relying on germline-encoded receptors to detect conserved viral signatures. Pattern recognition receptors (PRRs) ...

SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS-causing viruses. The discovery may ...

Innate lymphoid cells, which curiously behave like T cells even though they don’t recognize specific antigens, show promise as a potential cancer therapeutic. In the years that followed, other groups ...

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in unexpected ways—ways that have important implications for the development of ...

The novel coronavirus SARS-CoV-2 has an enzyme that can counteract a cell's innate defense mechanism against viruses, explaining why it is more infectious than the previous SARS and MERS-causing ...

The immune system can work in two ways: the innate immune system reacts to any foreign invaders that are identified by immune cells that look for such pathogens; but the acquired or adaptive immune ...

For decades, dogma dictated that the immune system consisted of two separate branches. Cells of the innate system respond rapidly to molecular patterns shared by a broad array of pathogens. Meanwhile, ...

Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. Clinical ...

The immune system is responsible for identifying and eliminating foreign pathogens. Cells work in an orchestrated fashion to ...

Unlike transient innate immune activation, trained immunity is characterized by long-lasting but reversible functional reprogramming of monocytes, macrophages, natural killer (NK) cells, and ...

A section of Goodsell et al.’s magnificent “Integrative illustration for coronavirus outreach” highlighting the packaging of the viral genetic material (in pink) by the scaffold “nucleocapsid protein” ...