Or say that this is the main street of Iowa, its most traveled road. I could tell you that it's a road of extremes, this busiest-of-the-busiest-in-Iowa stretch of I-80 from Des Moines to Davenport.

Off Interstate 80 in eastern Iowa is what is perhaps one of the most uniquely American establishments ever created: the Iowa 80 Truckstop, the self-proclaimed “world’s largest truck stop.” A ...

There’s not much on Interstate 80 as you cross Nevada between Reno and Salt Lake City—except for the Ruby Mountains, which spike straight up from the desert floor of the Great Basin.

There are lots of road-food choices along the heavily trafficked I-95 Northeast corridor, but it's hard to beat Pepe's, midway between New York and Boston and less than 5 minutes off the interstate.