The requirement for metabolic efficiency forces cancer cells to generate sufficient energy equivalents to support their high proliferative activity. One cycle of glycolysis supplies cells with two ...

Citrin deficiency is an autosomal recessive disorder arising from mutations in the SLC25A13 gene. The deficiency impairs the mitochondrial aspartate–glutamate carrier, which is a key component of the ...

Background: Hyperthyroid induced cardiac hypertrophy is related to increased cardiac workload. These changes are associated with an upregulation of metabolic pathways associated with energy production ...

To date, just 3 previous reports have detailed cases of mitochondrial malate dehydrogenase deficiency (MDH2D), and there are no known cures. A recent case report is putting a spotlight on a new ...

Researchers at MedUni Vienna have discovered that neurons have an emergency back-up system to enable them to remain functional even when their energy supply is disrupted. As in many areas of ...