Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the digestive tract, and most GISTs have oncogenic KIT gene mutations, which encode constitutively activated forms of ...
This is a preview. Log in through your library . Abstract Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect ...
One hundred fourteen women with T2-4 N0-1, estrogen receptor (ER) α–positive tumors were randomly assigned to neoadjuvant letrozole or letrozole plus metronomic cyclophosphamide. Twenty-four tumor ...
Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway. In BRAF-driven melanoma cells treated with BRAF inhibitors, subpopulations of cells escape ...
The Plant Cell, Vol. 26, No. 8 (AUGUST 2014), pp. 3358-3371 (14 pages) When multiple mitogen-activated protein kinase (MAPK) components are recruited recurrently to transduce signals of different ...
Erasca, Inc. presents promising preclinical data on ERAS-0015 and ERAS-4001 targeting RAS/MAPK pathway cancers at AACR meeting. Erasca, Inc. presented new preclinical data at the American Association ...
Functional telomeres protect chromosome ends and play essential roles in stem cell maintenance and differentiation. Over the past decade, telomeres have attracted increasing attention due to their ...
In Alzheimer’s disease, proteins in the brain pile up in plaques and tangles. Could the proteome yield clues on how that happens that genomic and transcriptomic studies miss? In today’s Nature ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results
Feedback