Mewtwo Strikes Back, which has since been remade as a 3D animated film, depicts Mewtwo before it broke free of the lab it was created in, floating in a glass tube, listening to the people around it.

For Mewtwo, the basis was Mew. For Shadow, the basis was not, actually, Sonic — at least not in universe. The legendary Pokémon and the moody 'edgehog are both synthetic beings, made in labs by ...

If you want to be the best like Ash Ketchum, you’ll need to prove yourself by defeating all Gym Leaders in Mewtwo. Can you do it? Of course. Capture Pokémon and train them, and soon ...