Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. However, these drugs are subject to treatment resistance. Scientists at St.

Randomized phase II trial of intravenous ascorbic acid (AA) as an adjunct to pazopanib for metastatic and unresectable clear cell renal cell carcinoma (ccRCC): A study of Academic and Community Cancer ...

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. However, these drugs are subject to treatment resistance. Scientists at St.

Clinical outcome of patients (Pts) with metastatic renal cell carcinoma (mRCC) progressing on front-line immune-oncology based combination (IO-COMBO) regimens. This is an ASCO Meeting Abstract from ...

A recent study published in Cancer Gene Therapy examined the genetic contributions of mesenchyme homeobox 2 (MEOX2) and switch/sucrose non-fermentable-related matrix-associated actin-dependent ...

The Putluri lab focuses on understanding the molecular mechanisms underlying bladder cancer development and tumorigenesis. Their research interests involve several key areas: The lab explores how ...

Renal medullary carcinoma (RMC) is characterized by the complete loss of the SMARCB1 tumor suppressor, and it predominantly affects individuals with sickle cell trait (SCT), characterized by increased ...

When a cell divides, it retains information about how to grow and instructions about what type of cell to become. Scientists at St. Jude Children's Research Hospital have gained a new understanding of ...

Atypical teratoid rhabdoid tumors (ATRT) are a rare, fast-growing form of brain cancer that usually strikes children three years and younger, though they can occur in older children and adults. There ...

(Memphis, Tenn.—May 9, 2022) Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children. However, these drugs are subject to treatment ...