Assembly of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) complex is an essential step for neurotransmitter release in synapses. The presynaptic plasma membrane ...

Synaptic vesicle docking and fusion are mediated by the assembly of a stable SNARE core complex of proteins, which include the synaptic vesicle membrane protein VAMP/synaptobrevin and the plasmalemmal ...

In 2013, James E. Rothman, Randy W. Schekman, and Thomas C. Südhof won the Nobel Prize in Physiology or Medicine for their discoveries of molecular machineries for vesicle trafficking, a major ...

Every time a hormone is released from a cell, every time a neurotransmitter leaps across a synapse to relay a message from one neuron to another, the cell must undergo exocytosis. This is the process ...

To release neurotransmitters, nerve terminals must repeatedly break down and rebuild specialized protein complexes, and the fidelity of this process may rely on α-synuclein, a protein that misfolds in ...

SNARE proteins are a large protein superfamily consisting of more than 60 members in yeast and mammals. The primary role of these proteins is to mediate fusion of vesicles with their target membrane ...

For this article, Eugene Russo interviewed Axel T. Brunger, a Howard Hughes Medical Institute investigator and professor of molecular and cellular physiology at Stanford University. Data from the Web ...

KAIST researchers discovered that NSF unravels a single SNARE complex using one round ATP turnover by tearing the complex with a single burst, contradicting a previous theory that it unwinds in a ...