Two-stage randomized trials are growing in importance in developing adaptive treatment strategies, i.e. treatment policies or dynamic treatment regimes. Usually, the first stage involves randomization ...

The correct application of the variance inflation factor approach for sample size calculations in trials that randomize intact clusters of individuals rests on knowledge of the variance of the outcome ...

The selection of suitable outcomes and sample size calculation are critical factors in the design of a randomised controlled trial (RCT). The goal of this study was to identify the range of outcomes ...