Fragmentomics based analysis of cell-free DNA (cfDNA) has recently emerged as a method to infer epigenetic and transcriptional data. Many of these reports analyze whole genome sequencing (WGS) which ...
In a single experiment, scientists can decipher the entire genomes of many patient samples, animal models or cultured cells. To fully realize the potential to study biology at this unprecedented scale ...
Biobank-scale sequencing studies have enabled the analysis of rare variants contributing to complex traits. Here we introduce MetaSTAARlite, a scalable and resource-efficient summary statistics-based ...
Long-read sequencing technologies analyze long, continuous stretches of DNA. These methods have the potential to improve researchers' ability to detect complex genetic alterations in cancer genomes.
Understand the stages of a standard RNA-seq bioinformatics workflow, including the role of QC, alignment, gene expression quantification, and specialized application analyses Identify key QC metrics ...
Genome editing lets scientists rewrite DNA, the instruction manual inside every living cell, with a precision that was unthinkable a generation ago. Technologies such as CRISPR have made this almost ...
DNA methylation is a highly studied epigenetic modification that is involved in regulating genome function and plays fundamental roles in development and disease. 1 It is linked to a broad range of ...
Combined Transcriptome and Circulating Tumor DNA Longitudinal Biomarker Analysis Associates With Clinical Outcomes in Advanced Solid Tumors Treated With Pembrolizumab The prognostic model demonstrated ...
This article and associated images are based on a poster originally authored by Marisa Amato and presented at ELRIG Drug Discovery 2025 in affiliation with Singleron Biotechnologies GmbH. This poster ...
Genome sequencing has revealed insights into how current-day residents of the Faroe Islands can trace their ancestry to a North Atlantic founder population and how evolutionary forces have shaped ...
SAVANA uses a machine learning algorithm to identify cancer-specific structural variations and copy number aberrations in long-read DNA sequencing data. The complex structure of cancer genomes means ...
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