G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...
The sweet-taste receptor might be the first stop in a metabolic surveillance system for sugar. The receptor is also expressed in certain intestinal cells, where it may facilitate glucose absorption ...
The approval of the GLP-1 receptor agonist semaglutide for weight regulation in January 2023 ushered in a new era of obesity therapy. In recent months, however, drug regulatory authorities have also ...
Retatrutide (LY3437943) is an agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors. Its dose–response relationships with respect to side effects ...
For the first time, researchers have determined how a human olfactory receptor captures an airborne scent molecule, the pivotal chemical event that triggers our sense of smell. Whether it evokes roses ...
What we can learn from fish calcitonin and its receptor: Evolutionary insights and medical potential
In fish, multiple HBD of CTR and stable ɑ-helix of calcitonin contribute to the high binding affinity and slow dissociation, thus triggering prolonged AC/cAMP signaling. In humans, RAMP dependent ...
The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.
GLP 1 receptor agonists were associated with higher incident chronic cough in adults with type 2 diabetes, with risk persisting even after excluding patients with reflux diagnoses.
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