Research continues to emerge showing that alcohol is bad for our health, increasing the risk of at least seven different types of cancer, disrupting sleep and hurting mental-wellbeing. Now, scientists have uncovered the exact number of years drinking could cut from your lifespan—and how many drinks per week produce the worst health outcomes.

People who consumed high amounts of alcohol were more likely to have brain lesions and cognitive decline, according to a new study that examined the brains of heavy drinkers.