When the coronavirus SARS-CoV-2 turned our world upside down, mRNA vaccines against COVID-19 brought a breakthrough. Their ...

How does the cell convert DNA into working proteins? The process of translation can be seen as the decoding of instructions for making proteins, involving mRNA in transcription as well as tRNA. But ...

In a new study, scientists from Johns Hopkins Medicine report that an experimental mRNA-based platform has the potential to help deliver next-generation mRNA therapeutics, including vaccines to fight ...

A new review synthesizes preclinical and clinical evidence showing that lipid nanoparticle biodistribution, mRNA persistence, ...

How delivery plays a new role as the key to success in mRNA application across therapeutic approaches For much of the past ...

During translation, multiple ribosomes travel along the nucleic acid chain to build polypeptides that become functional proteins. Occasionally, these molecular decoders pause on the mRNA, either ...

Scientists discover why ribosomes misread certain modified mRNA sequences and show how simple sequence changes could improve vaccine design and safety.

Transcription and translation are processes a cell uses to make all proteins the body needs to function from information stored in the sequence of bases in DNA. The four bases (C, A, T/U, and G in the ...

Researchers redesigned lipid nanoparticles to cut liver accumulation of locally injected mRNA by up to eighty-fold in mice ...

A pink ribosome surrounds part of a red-and-yellow helix-shaped strand of messenger RNA while a yellow protein branch extends from the ribosome. A graphic representation of a ribosome (pink) ...

Vaccines have been reliably and affordably protecting people from diseases worldwide for centuries. Until the COVID-19 pandemic, however, vaccine development was still a long and idiosyncratic process ...