The No. 12 seed in the Midwest, the McNeese State Cowboys (27-6) begin their pursuit of a Cinderella-run in March against the No. 5 seed, the Clemson Tigers (27-6). The Cowboys won the Southland Conference. The Tigers lost to Louisville in the semifinals of the ACC Tournament.

McNeese State comes into the tournament and wins the Southland conference dominantly. Clemson lost in the ACC tournament to Louisville but is one of the most experienced teams. It’s time to continue our College Basketball odds series with a McNeese-Clemson prediction and pick.

It’s Clemson Tigers vs McNeese State Cowboys in March Madness bracket. Here’s our prediction for the 2025 NCAA Tournament basketball game.