In this study, we aim to explore the effects of short hairpin RNAs (shRNAs) targeting human telomerase reverse transcriptase (hTERT) on the proliferation and apoptosis of osteosarcoma cells. After the ...

Cell therapy developer Celyad Oncology is using short-hairpin RNA (shRNA) to create T cells that can be used as an “off-the-shelf” allogeneic therapy for cancer patients. They are also using the ...

Researchers from the Biogerontology Research Foundation , Department of Molecular Neuroscience at the Swammerdam Institute for Life Sciences at the University of Amsterdam, and the Department of ...

The identification of the cellular targets of small molecules with anticancer activity is crucial to their further development as drug candidates. Here, we present the application of a large-scale RNA ...

RNA interference is an effective mechanism for gene silencing whereby double-stranded RNA triggers the cleavage and subsequent degradation of homologous transcript sequences. In this evolutionarily ...

Short hairpin sequences are encoded within a DNA vector and then introduced inside cells using plasmid transfection or viral transduction. The short hairpin RNA may either be in the firm of simple ...

Using the shRNA collections of The RNAi Consortium (TRC), the MISSION LentiPlex Pooled shRNA Libraries enable genome-wide RNAi screening at the bench-top level in a powerful, pooled lentiviral format.

STUART, Fla.--(BUSINESS WIRE)--Cognigenics, a pioneering company in RNA-based therapeutics for neuropsychiatric conditions and neurocognitive disorders, announced the publication of its latest ...