Background: STK-012 is a first-in-class α/β-IL-2R biased partial agonist designed to drive antitumor activity by selectively stimulating CD25+ antigen activated T cells, while avoiding hallmark IL-2 ...

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio (avelumab), a ...

AbstractAge at diagnosis among patients with cancer is a predictor of pathogenic germline variant prevalence, yet age thresholds often misclassify genetic risk. We performed germline sequencing of ...

In pts with gBRCAm early TNBC, 18 wks of targeted therapy using PARPi and anti-PD1 agents, with or without 3-week PARPi lead-in, resulted in a pCR rate of 50%, and a statistically significant increase ...

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AbstractBackground:. Computational pathology has successfully incorporated artificial intelligence (AI) methodologies for various applications, including the predictions of therapeutic response, ...

Abstract. We have discovered a novel KRAS G12D-degrading Molecular Glue using IPS's cutting-edge ProGlu AI-based drug discovery platform and PPIExplorer, an IPS-Chip based Proteomics technology.

AbstractAim:. Cost-effective or accessible methods to detect kidney cancers, especially those with renal insufficiency, remain elusive. We propose ultrasound molecular imaging (UMI) using microbubbles ...

Abstract. Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a five-yearsurvival below 12%. This poor prognosis stems from the ...

Abstract. Leucine-rich repeat-containing protein 15 (LRRC15) is a transmembrane protein involved in cell-cell and cell-extracellular matrix interactions. It is overexpressed in tumors of mesenchymal ...

Abstract. Advances in cancer prevention, early detection, and treatment have led to substantial improvements in cancer outcomes in the United States over the past several decades. Despite this ...