The favored Padres (-179 on the moneyline) take the field at home against the Marlins (+149). The San Diego Padres will give the start to Stephen Kolek (2-1, 2.84 ERA), who is looking for win No. 3 on the season, and the Marlins will counter with Max Meyer (3-4, 4.15 ERA).

The Padres took Game 1 of the series, 4-3 yesterday behind a Manny Machado homer in the bottom eighth. San Diego has followed up a six-game losing streak with three victories in the past four games. Miami’s two-game winning streak was snapped yesterday as the Marlins are 2-4 in the last six.

Pregame analysis and predictions of the Miami Marlins vs. San Diego Padres MLB game to be played on May 27, 2025 on ESPN.

King is dealing with a scapula issue after sleeping in an awkward position ahead of Saturday's start. More news: Padres Expected to Be Interested in 30-Homer Japanese Slugger Comi

A day after scratching Michael King from a scheduled start in what they described as a precautionary move, the San Diego Padres placed the right-hander on the 15-day injured list with inflammation in his throwing shoulder.

Manny Machado hit a tying homer in the eighth inning and Tyler Wade scored the winning run on Cade Gibson's wild pitch in the 11th as the San Diego Padres rallied past the Miami Marlins 4-3.