RNA editing covalently alter the nucleotide sequence of RNA transcripts relative to that of the encoding DNA, thereby contributing to gene diversity 1. One of the most prevalent RNA modifications is ...

This study evaluated Roche’s EndoCleave endonuclease against commercial benchmarks using a transient transfection platform with suspension HEK293 cells.

Figure 1: Characterization of L1 retrotransposition insertions in V3 cells. Figure 4: Model for EN i retrotransposition in NHEJ-deficient cells containing dysfunctional telomeres. Genomic DNA was ...

MutLα (MLH1—PMS2) is a latent endonuclease that is activated in a mismatch-, MutSα-, proliferating cell nuclear antigen (PCNA)-, replication factor C (RFC)-, and ATP-dependent manner, with nuclease ...

Restriction endonuclease analysis of chromosomal DNA was applied to thirteen Listeria monocytogenes strains alongside the more conventional typing methods of serotyping and phase typing. The organisms ...

The EndonucleaseGTP ELISA Kit from Cygnus Technologies detects and quantitates residual endonuclease impurities in recombinant vaccines and viral vectors used for gene therapy. The EndonucleaseGTP ...

CRISPR-Cas9 is a gene editing tool that is used to remove, edit, or add parts of the DNA within a genome. It consists of two critical components: a guide RNA and an endonuclease enzyme called Cas9.

Scientists first observed the biological phenomenon of restriction and modification in the 1950s, but they did not identify and isolate restriction enzymes until the late 1960s. 3 In 1970, Hamilton ...

Another potentially game-changing discovery has come out of the lab of Feng Zhang, PhD. This time, they uncovered the first programmable RNA-guided system in eukaryotes. Just a few months ago, the ...

Restriction fragment length polymorphism (RFLP) is a technique invented in 1984 by the English scientist Alec Jeffreys during research into hereditary diseases. It is used for the analysis of unique ...