The Sepsis-1, Sepsis-2, and Sepsis-3 definitions are for adult sepsis. The IPCC (International Pediatric Sepsis Consensus Conference) and Phoenix definitions are for pediatric sepsis. ARDS denotes ...

Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma ...

Participants received CD68-ET3-LV–transduced autologous CD34+ HSCs at doses of 5.0×10 6 to 6.1×10 6 per kilogram of body weight. The vector copy numbers in the final drug product were 1.0 and ...

Dr. Kathleen M. McFadden (Medicine): A 22-year-old woman was transferred to this hospital in the summer before the coronavirus disease 2019 pandemic because of headache, fever, and respiratory ...

Xalnesiran, a small interfering RNA molecule that targets a conserved region of the hepatitis B virus (HBV) genome and silences multiple HBV transcripts, may have efficacy, with or without an ...

Cell-free DNA (cfDNA) sequence analysis to screen for fetal aneuploidy can incidentally detect maternal cancer. Additional data are needed to identify DNA-sequencing patterns and other biomarkers ...

B-cell acute lymphoblastic leukemia (B-cell ALL) is the most common childhood cancer. Despite a high overall cure rate, relapsed B-cell ALL remains a leading cause of cancer-related death among ...

A woman with TEMPI syndrome who had a second relapse after many years of disease control with myeloma-type therapy had a rapid response to teclistamab, a bispecific antibody targeting plasma cells.

Data are needed from randomized trials on a long-term antithrombotic treatment strategy for patients with atrial fibrillation and stable coronary artery disease. New research findings are ...

The authors describe the science behind a clinical trial of a combination of therapies, including xalnesiran, to treat chronic hepatitis B virus infection. This editorial was updated on December 5 ...

The efficacy of trastuzumab deruxtecan after endocrine-based therapy in patients with metastatic breast cancer with low expression of human epidermal growth factor receptor 2 is unknown.

For patients with chronic hepatitis B virus infection, standard care involves lifelong treatment and rarely leads to functional cure. New research findings on the investigational antiviral agent ...