In the span of a week, the San Francisco 49ers are watching their running backs drop like flies. Superstar Christian ...

When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

More and more you could make an argument the most dangerous job is that of running back for the San Francisco 49ers.

Breaking down all of the good and some of the bad from the 49ers’ much-needed blowout win over the Bears in Week 14.

Moments after the conclusion of the game, a 44-42 thriller that ended with the Bills dropping only their third game of the ...

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

No Christian McCaffrey has been no problem for the 49ers in the first quarter of Sunday's game against the Bears.

An injury-riddled season for the San Francisco 49ers has hit hardest in the backfield, with both Christian McCaffrey and ...

SportsLine's model simulated Chicago Bears vs. San Francisco 49ers 10,000 times and made its Week 14 NFL picks, predictions ...