A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...

Porcine reproductive and respiratory syndrome virus (PRRSV) continues to devastate the global swine industry, yet the ...

Abl1, a nonreceptor tyrosine kinase closely related to Src kinase, regulates critical cellular processes like proliferation, differentiation, cytoskeletal dynamics, and response to environmental cues ...

The AMP transferase, FICD, is an emerging drug target fine-tuning stress signaling in the endoplasmic reticulum (ER). FICD is a bifunctional enzyme, catalyzing both AMP addition (AMPylation) and ...

About Variational AI. Variational AI is redefining the unit economics of drug discovery through the power of generative AI. The founding machine learning (ML) team comes from leading AI research labs ...

EEA1-Rab5 Molecular Motor. Motor proteins are remarkable molecular machines within a cell that converts chemical energy, stored in a molecule called ATP, into mechanical work. The most prominent ...

However, neither biochemical measurements nor mass spectrometry is capable of detecting the ATP dip because of their insufficient time and space resolution. Therefore, an ATP imaging approach using ...

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It is not difficult to calculate that the energy liberated by the conversion of 1 mole of ATP to the energy of one molecule of ATP amounts to 6.64 × 10 −20 joules, which can be related to the standard ...

Hypertrophic cardiomyopathy (HCM) is a genetic disease of the myocardium characterized by a hypertrophic left ventricle with a preserved or increased ejection fraction. Cardiac hypertrophy is often ...