Nature

Catalytic Isomerization of Allylic Alcohols

Catalytic isomerization of allylic alcohols represents a versatile approach to convert readily available unsaturated alcohols into more synthetically valuable carbonyl compounds. By shifting a ...
Nature

Enantioselective Decarboxylative Reactions in Organic Synthesis

Enantioselective decarboxylative reactions harness the release of carbon dioxide from carboxylic acids to generate reactive intermediates—most commonly enolates or their mimics—under relatively mild ...
C&EN

Diastereoselective Alkylation of β-Amino Esters: Structural and Rate Studies Reveal Alkylations of Hexameric Lithium Enolates

Contribution from the Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, Physics Department, Clark Hall, Cornell University, Ithaca, New ...
C&EN

Synthesis of Filibuvir. Part I. Diastereoselective Preparation of a β-Hydroxy Alkynyl Oxazolidinone and Conversion to a 6,6-Disubstituted 2H-Pyranone

† Chemical Research and Development and ‡ Analytical Research and Development, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, 06340 Connecticut Chemical Research and ...