While Drew Barrymore has had her share of on-screen kisses with various actors throughout her career, there’s only one person who tops the list. During an appearance on Wednesday’s episode of “Watch What Happens Live with Andy Cohen,” Barrymore opened up about her chemistry with longtime friend Adam Sandler.

Drew Barrymore called friend Adam Sandler her best on-screen kiss and said, 'We're representing something bigger than hot, sexual chemistry. We're representing true admiration of another person.'