Questionable along with Bosa, Greenlaw and Guerendo is defensive tackle Khalil Davis, who has a knee injury. Linebackers Demetrius Flannigan-Fowles (knee) and Dee Winters (ankle), defensive ends Yetur Gross-Matos (knee) and Sam Okuayinonu (wrist) and safety Talanoa Hufanga (wrist) are all cleared to go after appearing on the injury list.

While the 49ers will be without left tackle Trent Williams for a fourth straight game on Thursday night, there's at least a chance for three other key players to be available against the Rams.

Nick Bosa has been declared doubtful for Sunday's game with a hip/oblique injury while several other Niners are slated to miss the game.

The San Francisco 49ers are preparing for their Week 15 contest against the Los Angeles Rams on Thursday at Levi's Stadium in Santa Clara, California.

Kyle Shanahan shared his team's pre-practice injury report at a Tuesday press conference and it was the same as Monday's estimated one, so several key players are on the sideline ahead of Thursday's game against the Rams.

The San Francisco 49ers are facing another setback as defensive lineman Nick Bosa is officially out for Sunday's game. Meanwhile, there is some good news for the injury-ravaged team as safety Talanoa Hufanga was activated from the injured reserve.

Superstar edge rusher Nick Bosa is officially ruled out for Sunday's contest against the Bears, according to ESPN's Adam Schefter. The 27-year-old defender was dealing with hip and oblique injuries. This will be his third consecutive game missed for the 49ers.