Aiyuk was placed on the physically unable to perform list when training camp opened last month. The former first-round pick is recovering from a torn ACL and MCL he suffered in Week 7 against the Kansas City Chiefs during the 2024 season. If Aiyuk starts the regular season on the PUP list, he'd be required to miss at least four games.

San Francisco 49ers coach Kyle Shanahan provided a rough estimation for when injured wide receiver Brandon Aiyuk could return to the field.

49ers receiver Brandon Aiyuk continues to rehab from tearing his ACL and MCL in October of last season. With Aiyuk still on the physically unable to perform list, General Manager John Lynch noted in a Thursday interview with KNBR that there is not a true timetable for Aiyuk’s return to play.