A single center retrospective cohort study of patients with metastatic breast cancer and leptomeningeal disease: Updated survival data and subgroup analyses by breast cancer subtype. Updated safety ...
The cyclic adenosine monophosphate (cAMP) pathway is among the most important of the complex of molecular networks that control life. As a major secondary messenger, cAMP passes hormonal and ...
New research has shown that cells regulate cAMP/PKA signaling by forming liquid droplets that segregate excess PKA catalytic subunits where they can do no harm. Some cancers may block the formation of ...
In a rat model of chronic heart failure, Xijiaqi Formula improved cardiac indices and rescued learning/memory deficits while ...
Anchored Protein Kinase-A (PKA) bound to A-Kinase Anchoring Protein (AKAP) mediates the effects of localized increases in cAMP in defined subcellular microdomains and retains the specificity in ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 20 (Oct. 1, 2002), pp. 13217-13221 (5 pages) Changes in hippocampal function seem critical for cognitive ...
Mount Sinai Researchers Find "Removal of AKAP11 Protein by Autophagy as a key to Fuel Mitochondrial Metabolism and Tumor Cell Growth through activating protein kinase A (PKA) (Patent pending)" ...