The Los Angeles Rams and San Francisco 49ers aren't in a "must-win" situation, yet the loser of this "Thursday Night Football ...

Since training camp, the 49ers season hasn't gone as planned amid injuries to star players and on-field struggles.

On Thursday night, the San Francisco 49ers will host the Los Angeles Rams at Levi's Stadium in what is a must-win game for them and their playoff hopes.

San Francisco 49ers tight end George Kittle is one of six players nominated for the FedEx Air & Ground Player of Week 14 ...

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Isaac Guerendo was nominated for the Pepsi Zero Sugar Rookie of the Week Award for Week 14 after scoring two touchdowns in his first-career start.

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

How high did the Dolphins and 49ers rise and how far did the Bears fall in our Week 15 Power Rankings? Plus, we look at the ...

McCaffrey's old backfield mate discussed the trials and tribulations of a season-ending injury on his podcast.

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San ...