Dalton Del Don looks at the biggest fantasy football topics for Week 6, including the potential for an encore performance from Rico Dowdle.

Fantasy Impact: ESPN’s Kris Rhim posits that the Chargers could be forced to lean on rookie running back Omarion Hampton in a way they “didn’t anticipate” in 2025. It would certainly make sense after Hampton erupted for 135 yards from scrimmage and a touchdown against the Broncos. Hampton vaults into the RB1 tier for the remainder of the season.

Matchups are the key to fantasy lineup decisions. Here are the most and least favorable for Week 6 at QB, RB, WR and TE.

The Week 6 NFL schedule opens with a NFC Eest rivalry game with the New York Giants set to host the Philadelphia Eagles on 'Thursday Night Football.' Kickoff is scheduled for 8:15 p.m. ET at MetLife Stadium.

Arizona Cardinals quarterback Kyler Murray suffered a foot injury in Week 5 and now has missed practice to start the week as the Cardinals prepare for the Indianapolis Colts. Head coach Jonathan Gannon would only say "we'll see" as to whether Murray would be able to play this week,

Yes, the quarterback play in Vegas must improve. Geno Smith leads the league in interceptions with nine, and he threw two picks in Week 4 against Chicago while targeting Meyers, relying on arm talent to win late in the down. That's trouble.

The reaction to this news at the quarterback position is probably minimal in one-QB leagues. Neither Flacco or Browning matters much in that format. But in Superflex leagues, Flacco does become a must-roster again.