With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the ...

When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

McCaffrey's old backfield mate discussed the trials and tribulations of a season-ending injury on his podcast.

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after hurting his foot?

Already missing five starters during the blowout loss to the Bills, San Francisco lost star running back Christian McCaffrey ...

Isaac Guerendo will make his first NFL start on Sunday as the injury-depleted San Francisco 49ers face the Chicago Bears. The ...

The rookie running back showed off on an impressive drive that included a long catch and TD run against the Bears.

No Christian McCaffrey has been no problem for the 49ers in the first quarter of Sunday's game against the Bears.