The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five ...

After that, there is no significant NFL talent on the 49ers roster, while the edges are equally deficient in both depth and ...

Heads have already started to roll at the San Francisco 49ers. Entering the final third of the regular season, management ...

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

The San Francisco 49ers reportedly made a move on Friday. According to Eric Branch of The San Francisco Chronicle, the 49ers ...

Following new injury reports, updated simulations reveal the best bet for 49ers vs. Bills on Sunday Night Football. Injury ...

First comes Brock Purdy, the team's star quarterback, who missed Week 12 with a right shoulder. While Purdy is still ...

The San Francisco 49ers are making changes to their WR group ahead of an important road trip to face the Buffalo Bills. The ...