Explore the impact of lysosomal lipid recycling in a rare multi-organ disorder linked to the SPNS1 gene mutations.

AI has advanced molecule design, yet synthetic feasibility remains a bottleneck. Chemistry-first approaches offer a practical ...

Scientists have linked rare mutations in SPNS1 to a previously unknown lipid recycling pathway in lysosomes, revealing how faulty fat processing can trigger muscle and liver disease.

New research has discovered how Rab proteins control the delivery of critical supplies to strengthen neural connections, providing researchers with important insights into memory formation and ...

Drug discovery now costs 100 times more per FDA-approved drug than in 1950, despite vast advances in biology and computing. The core problem is the collapse of predictive validity in preclinical ...

14 October 2025 | By Dr Jack Scannell (CEO of Etheros Pharmaceuticals Corp), Dr Raminderpal Singh (Hitchhikers AI and 20/15 Visioneers) Drug discovery now costs 100 times more per FDA-approved drug ...

New research has demonstrated how tiny tweaks in a DNA-sensing enzyme may hold the key to the naked mole-rat’s extraordinary lifespan – offering insights that could one day inform therapies for aging ...

The rise of personalised cancer immunotherapy represents a pivotal shift in oncology, aiming to harness the body’s own immune system to recognise and eliminate tumour-specific neoantigens. Encouraging ...

Measuring disease progression remains one of the biggest hurdles in CNS drug development. Eye movements, now trackable with just a laptop and webcam, are emerging as a sensitive and scalable biomarker ...