A disappointing 2024 saw the San Francisco 49ers miss the postseason and register a 6-11 regular season mark. Injuries to key players and positions contributed to much of that failure, and the team hopes to remain healthy in 2025. The biggest concern is star running back Christian McCaffrey, who missed much of last year with a number of ailments.

Ricky Pearsall nears return from injury as the San Francisco 49ers navigate wide receiver setbacks during training camp.

49ers star wide receiver Brandon Aiyuk is opening training camp on the active/physically unable to perform list and it doesn't appear he will be coming off it anytime soon. Aiyuk is recovering from a torn ACL and MCL suffered during a Week 7 loss to the Kansas City Chiefs last season and it remains unclear when he will return to the field in 2025.

The San Francisco 49ers reached Super Bowl LVIII, losing 25-22 to the Kansas City Chiefs, but didn't come close to last year's Super Bowl LIX as they missed the playoffs. The 49ers are hoping for a bounce-back season under bright-minded head coach Kyle Shanahan,

San Francisco 49ers WR Brandon Aiyuk injury timetable feels like a complete mystery and could have a huge impact on their season in 2025.

As the San Francisco 49ers prepare for the start of training camp this week, two of their star players had contrasting injury updates.