The 49ers just lost their second game in a row by at least 25 points for the first time since Jim Tomsula was the head coach.

One of the only 49ers who hasn't fallen short of expectations this season is George Kittle. After the 49ers' 35-10 loss to ...

Bills quarterback Josh Allen's fiancée, Hailee Steinfeld, is spotted for the first time since the couple announcement their ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

The Buffalo Bills hammered the San Francisco 49ers 35-10 in a snow-filled rout led by Josh Allen’s 4 TDs. Colin Cowherd ...

The wife of San Francisco 49ers offensive tackle Trent Williams announced their son, Trenton O'Brien Williams Jr., was ...

San Francisco has dropped three straight, including meek losses to the Packers and Bills by a combined 53 points, to drop to ...

San Francisco 49ers tight end George Kittle told reporters he had "no idea" why he received just two targets during a 35-10 ...

Buffalo Bills running back James Cook looked phenomenal in his team's Week 13 win over the San Francisco 49ers, and his ...

A Bills equipment cart awkwardly interrupted an NBC Sports Bay Area live segment after the 49ers' loss in Buffalo.

Matthew Berry, Jay Croucher and Connor Rogers dive into the ramifications of star Christian McCaffrey's latest injury, ...

San Francisco 49ers player Trent Williams and his wife Sondra are mourning the passing of their newborn son, the couple ...