Challenging centuries-old assumptions about thermodynamics, a new study published in Physical Review Letters has shown that ...

The conserved head structure, the membrane portion and the peripheral stalk (or stalks) together could have formed a translocase that coupled ATP hydrolysis to the transfer of RNA and/or proteins ...

J-domain proteins (JDPs) coevolved with Hsp70s to trigger ATP hydrolysis and catalytically upload various substrate polypeptides in need to be structurally modified by the chaperone. Here, we measured ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...

they injected ATP into ClC-3 protein samples before freezing to reduce hydrolysis. Researchers performed all-atom molecular ...