On March 13, 2025, Hugo Moreno-Mendez arrived at the McLennan County Probation Department in Waco, Texas, expecting a routine probation check-in. Instead, Immigration and Customs Enforcement officers ...

PARP inhibitors reshaped oncology when they first reached patients some 10 years ago, but they represent just one entry point into a much larger and more intricate biological network.

Scientists have discovered that a gene normally considered a DNA-protecting "good guy" can become dangerous when cells make too much of it. The gene, EXO1, acts like molecular scissors that help ...

A ground-breaking study has traced thousands of conserved regulatory elements back 300 million years, revealing deep principles of plant genome evolution – a discovery that could pave the way for more ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. A comprehensive understanding of the atomic level mechanism governing the binding ...

The global DNA polymerase market size is valued at USD 395.21 million in 2024 and is expected to reach USD 420 million in 2025. It is projected to grow significantly, reaching approximately USD 721.42 ...

Eukaryotic Polα-primase contains DNA polymerase (Pol1) and RNA primase subunits that together synthesize a >20-nucleotide hybrid RNA–DNA primer. Bacteria and archaea only require a dozen or less RNA ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

This patent describes a novel therapeutic strategy involving conjugate compounds that integrate a poly(ADP-ribose) polymerase (PARP) inhibitor moiety with a disease-targeting ligand, offering a ...