The study, published in Proceedings of the National Academy of Sciences of the United States of America, deepens ...
The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...
A new iScience study shows that the error-prone polymerase Pol ι is induced in BRCA2-deficient mammary epithelial cells, ...
DNA replication stress threatens genome stability, but how plants respond to this challenge remains unclear. Here we show that the evolutionarily conserved polymerase ...
New research shows that triple-negative breast cancer cells rely on shared DNA damage tolerance enzymes such as POLζ and CHK1 ...
A record player-like microscope and computer simulations solve a longtime mystery, showing that metal ions bridge DNA strands that would normally repel.
Bacteriophages, or viruses that infect bacteria, have a fiendishly simple purpose in life: attach to a bacterial cell, inject ...
Called Cas12a2, the CRISPR system had some distinctive properties. Rather than editing cells’ DNA when prompted by a guide RNA, as CRISPR-Cas9 does, Cas12a2 indiscriminately shreds it, ultimately ...
Late last month, Anthropic claimed it had discovered a curious stretch of DNA in a virus called a bacteriophage that repeats ...
Claude AI biology discovery: Anthropic's Claude Mythos 5 agents autonomously searched 1.9 billion protein clusters and identified ART, a previously uncharacterized enzyme system in bacteriophage DNA ...
東京医科大学（学長：宮澤啓介／東京都新宿区）医学総合研究所 未来医療研究センター ゲノムストレス応答学部門 塩谷文章 教授(特任)、京都大学大学院生命科学研究科 附属放射線生物研究センター ゲノム損傷応答学分野 五十嵐太一 特任助教、安原崇哲 教授らの研究グループは、がん遺伝子KRASによってDNA複製に強い負荷がかかった細胞が、複製の進め方を切り替えることで生き残る仕組みを明らかにしました。 が ...
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