San Francisco 49ers running back Christian McCaffrey and top backup Jordan Mason are being placed on injured reserve. Read ...

The 24-year-old Guerendo was a fourth-round pick in the 2024 NFL draft. He transferred to Louisville for the 2023 season ...

Christian McCaffrey’s initial diagnosis was correct. The San Francisco 49ers running back injured the PCL in his knee, an MRI ...

San Francisco 49ers head coach Kyle Shanahan revealed Sunday night that the team fears running back Christian McCaffrey ...

The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian McCaffrey leave their ...

Here's everything you need to know about the 49ers current RB depth chart following injuries to Christian McCaffrey and ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

The San Francisco 49ers plan to place running backs Christian McCaffrey and Jordan Mason on injured reserve after suffering ...

San Francisco 49ers running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the ...

A trying season for the San Francisco 49ers took two more hits after Sunday's loss to the Buffalo Bills. The one-time ...

Jennifer Lee Chan highlights potential external options the San Francisco 49ers could consider after injuries to Christian ...

An extremely disappointing season for Christian McCaffrey, which encapsulates the distressing tone of the San Francisco 49ers ...